Hypophosphatasia (HPP) Homeopathic Treatment: Best Remedies for Bone Strength

Published OnApril 4, 2025

Dr Vaseem Choudhary
Homeopathy remedies for Hypophosphatasia (HPP)

Hypophosphatasia (HPP) is a rare genetic disorder that affects bone and teeth mineralization due to mutations in the ALPL gene, which encodes the enzyme tissue-nonspecific alkaline phosphatase (TNSALP). The disease results in defective bone and tooth development, depending on the severity and age of onset.

Effects of Hypophosphatasia:

  1. Bone Abnormalities:

Soft, weak bones (osteomalacia)

Rickets-like symptoms in children

Frequent fractures 

Skeletal deformities (e.g., bowed legs)

  1. Dental Issues:

Premature loss of baby and permanent teeth

Weak or poorly developed ename

  1. Muscle and Movement Problems:

Muscle weakness

Poor motor development (in infants and children)

Joint pain or stiffness

  1. Respiratory Issues:

Weak chest bones, with breathing difficulties in infants

  1. Neurological Symptoms:

Seizures due to low vitamin B6

  1. Fatigue and General Weakness

Hypophosphatasia (HPP) is classified into different types based on the age of onset and severity. 

Types of Hypophosphatasia

  1. Perinatal Lethal HPP
  • Most severe form, fatal before or shortly after birth.
  • Severe skeletal abnormalities, underdeveloped lungs, respiratory failure with a complete lack of bone mineralization.
  1. Perinatal Benign HPP
  • Skeletal abnormalities may improve over time.
  • Seems to be lethal at birth but improves postnatally.
  1. Infantile HPP

Symptoms appear in the first six months of life

Poor growth, soft skull (craniosynostosis), and bowed legs

  1. Childhood HPP

Symptoms appear after infancy but before. The symptoms of hypophosphatasia (HPP) vary depending on the severity and type of the disease.

Common Symptoms of HPP

  1. Bone with Skeletal Issues
  • Weak, soft bones (osteomalacia, rickets-like symptoms) with  frequent fractures healing poorly
  • Bone deformities (e.g., bowed legs, short stature)
  • Skull abnormalities (soft skull, craniosynostosis in infants)
  1. Dental Problems
  • Premature loss of teeth
  • Weak enamel leading to cavities
  • Root abnormalities
  1. Muscle and Movement Problems
  • Muscle weakness with poor motor development
  • Delayed crawling, standing, or walking in infants
  • Joint pain and stiffness
  1. Respiratory Issues (Severe Cases)
  • Infants having weak rib cage leading to breathing difficulties.
  1. Neurological Symptoms (Severe Cases)
  • Seizures (due to low vitamin B6 metabolism
  • Infants with poor feeding and irritability
  1. General Symptoms

Growth delays or short stature with fatigue

Homeopathic Approach to Hypophosphatasia

Homeopathy aims to support overall health and manage symptoms of hypophosphatasia (HPP) by strengthening bones, improving mineral absorption, and reducing pain. Conventional treatments like enzyme replacement therapy are needed in severe cases. A homeopathic approach may help with symptom relief and quality of life.

Five Homeopathic Remedies for Hypophosphatasia

  1. Calcarea Phosphorica: Weak bones with slow healing fractures, stunted growth. It supports bone mineralization and strengthens teeth.
  2. Silicea: It can help with poor bone development, delayed closure of fontanelles in infants, and brittle nails and teeth. Medicine helps to enhance calcium absorption and strengthen bones.
  3. Symphytum Officinale: It helps with frequent fractures, bone repair, and slow healing.
  4. Phosphorus: It helps weak bones that have a tendency to break easily. 
  5. Ruta Graveolens: Used for joint pain and bone bruising. 

Diet Recommended: 

A well-balanced diet for hypophosphatasia (HPP) supports bone health and manages and avoids complications like excessive calcium buildup or kidney stones.

Recommended Foods for HPP

  1. Bone-Strengthening Nutrients:

Calcium-Rich Foods, Leafy greens, tofu, Nuts and seeds (sesame seeds, flax seeds)

  • Magnesium-rich bananas and avacados,

 helps with calcium absorption. 

  • Foods rich in antioxidants, like fatty fish and egg yolk, can be consumed.
  • Whole grains like Brown rice, quinoa, and oats can be taken.
  • Sunlight is the best natural source for maintaining vitamin D levels.
  • Phosphate levels are high in HPP, so there is no need to take extra food or supplements.
  1. Protein for strength of muscles and Bones:
  • Fish with salmon and sardines can be consumed.
  • Plant-based proteins like Lentils, chickpeas, and beans are suggested.
  1. Anti-Inflammatory Foods (for Bone Pain & Joint Health)
  • Patients are suggested to take Omega-3-rich foods like Walnuts, flaxseeds, chia seeds, fatty fish
  • Taking Turmeric & ginger with Natural anti-inflammatory properties helps
  • Green tea can be taken, which is rich in antioxidants

4: Foods to Limit or Avoid:

  • Excess Phosphates (HPP patients already have high phosphate levels)
  • Foods to avoid: Processed foods with phosphate additives, such as processed meats, soft drinks, fast food,

packaged snacks (chips, crackers, instant noodles)

5: Excess Calcium or Vitamin D Supplements: 

Taking calcium supplements can cause kidney stones and worsen symptoms. Calcium can be consumed from food. 

  1. Sugary and Acidic Food:

Avoid Soda, candy, and processed juices to protect the teeth.

FAQs

  1. How is hypophosphatidylase diagnosed?
  • Blood tests can be done to detect alkaline phosphatase levels, calcium and phosphorus levels
  • Genetic testing for ALPL gene mutations
  • X-rays are done to detect bone abnormalities.
  • Urine tests for High phosphoethanolamine levels
  1. What are the different types of hypophosphatemia?

HPP is classified into:

  • Perinatal Lethal HPP that is Severe, fatal at birth
  • Infantile HPP appears in the first six months; it can be life-threatening if untreated
  • Childhood HPP weakens bones with the loss of teeth earlier than normal.
  • Adult HPP stresses on fractures causing osteoporosis-like symptoms
  • Odontohypophosphatasia affects only teeth.
  1. Is there a cure for hypophosphatemia?

There is no cure, but enzyme replacement therapy (ERT) with asfotase alfa can improve symptoms in moderate to severe cases. Supportive treatments like physical therapy and pain management help.

  1. What is the life expectancy of someone with hypophosphatemia?
  • Perinatal lethal HPP can be fatal without treatment
  • Infantile HPP can be life-threatening, but survival improves with early ERT.
  • Mild to moderate reflects normal life but may have bone-related complications.
  1. What are the treatment options for hypophosphatemia?
  • Enzyme Replacement Therapy (ERT): Asfotase alfa improves bone strength and survival.
  • Pain can be managed well with NSAIDs and physical therapy 
  • Early Dental Care prevents tooth loss.
  • Advised to take a nutritional and balanced diet with moderate calcium and vitamin D.
  1. Can hypophosphatemia be prevented?

 HPP is a genetic disorder. Genetic counseling can help with the risk of passing it to the next generations.

  1. What lifestyle changes can help manage hypophosphatemia?
  • Patients are suggested with Gentle exercise like swimming or walking.
  • Taking a Balanced diet with calcium-rich foods, vitamin D, and  magnesium helps
  • Regular medical checkups to monitor bone health.

In conclusion, Homeo Care Clinic offers a holistic approach to treating the disease. The remedies mentioned above can treat the underlying causes of the condition and offer relief from the discomfort. However, it is important to consult a qualified homeopathic practitioner for the correct dosage and duration of treatment. Homeo Care Clinic provides comprehensive care for various ailments and offers customized treatment plans based on individual requirements.

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