Xanthomas are firm, raised, waxy-looking eruptions or papules that can appear in any part of the body. They are a result of cholesterol-rich material deposit in the skin which is abnormal fat levels.
Xanthomas many times skin-colored, pink, or yellow, and they can vary in size.
They are mostly in adults and people with high-level lipids in the blood
Cholesterol deposits under your skin then it forms xanthelasma
Xanthelasma–
soft, semi-solid, yellowish eruptions that usually appear on the eyelids.
They are not painful and not itchy .. rarely affect eye vision and eyelids
Xanthoma
A firm, waxy-appearing bump can appear on the arms and legs. Xanthomas are skin-colored, pink, or yellow. If the presence of xanthomas then there may be abnormal levels of lipids in the blood.
About half of the people with xanthelasma have high cholesterol levels.
Causes Of Xanthomatosis
- Hyperlipidemias – high level of lipids in the blood.
This can increase your risk of heart attack and stroke because blood cannot flow easily through arteries.
Causes of hyperlipidemia
obesity, saturated fat intake, and the cholesterol content diet in a person’s diet.
Familial hypercholesterolemia –it is an inherited genetic disease ..it causes high blood cholesterol and LDL. It is single generation disorder,
Affecting lipoprotein metabolism.
Dysbetalipoproteinemia–a rare genetic disorder that includes high levels of cholesterol and triglycerides in the blood:
It was diagnosed by the presence of the APOE genotype and the dysbetalipoproteinemia phenotype.
Hypertriglyceridemia– high level of triglycerides (fats) in the blood ..Very high levels of triglycerides can cause pancreatitis, and sometimes loss of appetite.
Causing abdominal pain, nausea, and vomiting, this symptoms also present in some patients also gastrointestinal pain/difficulty breathing/ memory loss.
- Endocrine disorders:
Diabetes mellitus
Hypothyroidism
Treatment Of Xanthomatosis
Treatment depends on the underlying cause. Lifestyle changes like diet and exercise can help improve lipid levels. Also medications like statins, ezetimibe, PCSK9 inhibitors, and bile acid.
xanthomas are painful or cause emotional distress, surgical excision is also useful
ERUPTIVE XANTHOMAS is harmless
Xanthoma Disseminatum
Treatment includes surgical excision, laser ablation, systemic medications, and radiotherapy also used.
Cerebrotendinous xanthomatosis (CTX)
Treatment includes chenodeoxycholic acid (CDCA) replacement therapy to help the body break down cholesterol.
Cerebrotendinous xanthomatosis (CTX)
patients may also need cataract surgery by age 50.
Diabetes and cholesterol levels that are well-controlled it also useful to maintain.
surgical removal, laser surgery, or chemical treatment is also suitable for these eruptions and lesions.
Developing psoriasis is linked to high LDL (bad) cholesterol levels, causing raised, red, itchy patches of skin.
manage your cholesterol with diet, exercise, and in some cases, cholesterol-lowering medication also take.
Lifestyle changes
low-fat, high-fiber intake diet (e.g., Mediterranean or plant-based diet
Increase physical activity and maintain a healthy weight.
Avoid alcohol and smoking.
Treat conditions like hypothyroidism, diabetes, or nephrotic syndrome.
Periodic screening for cardiovascular risk factors.
Maintain optimal control of diabetes, thyroid dysfunction, and other metabolic conditions.
Cryotherapy: For small xanthomas in certain cases.
Omega-3 fatty acids: To reduce triglycerides
Fibrates: Lower triglycerides (e.g., fenofibrate, gemfibrozil).
Symptoms Of Xanthomatosis
The symptoms of xanthomatosis are related to the presence of xanthomas, which are fatty deposits in the skin, tendons, or other tissues.
The symptoms also depend on the size and location of XANTHOMAS.
Common Symptoms
- Skin Lesions–Yellowish to orange, raised, or flat lesion.
Larger or inflamed xanthomas may cause
tenderness.
Tendinous xanthomas can impair joint movement and cause pain.
Also, symptoms depend on XANTHOMAS types –
Eruptive Xanthomas: appear suddenly on the buttocks, shoulders, and thighs.
itchy and associated with very high triglycerides.
Tendinous Xanthomas: Firm, movable masses along tendons.
Plane Xanthomas: yellowish patches on the skin, eyelids (xanthelasma), palms.
Cardiovascular Symptoms: Chest pain or signs of atherosclerosis
Neurological Symptoms (in rare genetic disorders like cerebrotendinous xanthomatosis): ataxia, or seizures.
FAQS–
Can xanthomatosis be life-threatening?
Ans- They are often a symptom of an underlying condition, such as severe hyperlipidemia, which increases the risk of cardiovascular disease, including heart attack or stroke.
How is xanthomatosis diagnosed?
Ans- By Physical examination of skin lesions.
Lipid profile to measure cholesterol and triglyceride levels.
Biopsy of the lesion to confirm lipid-laden macrophages.
Can xanthomas go away on their own?
Ans -lowering cholesterol or triglyceride levels through lifestyle changes or medications can help reduce the size of xanthomas.
Is xanthomatosis hereditary?
Ans- Some forms of xanthomatosis are hereditary, such as familial hypercholesterolemia or cerebrotendinous xanthomatosis, which result from genetic mutations affecting lipid metabolism.
Can xanthomatosis be prevented?
Ans- While genetic causes cannot be prevented, you can reduce the risk of xanthomatosis by:
- Maintaining healthy cholesterol and triglyceride levels.
- Eating a balanced diet low in saturated fats.
- Regular exercise and weight management.
In conclusion, Homeo Care Clinic offers a holistic approach to treating Xanthomatosis. The remedies mentioned above can treat the underlying causes of the condition and offer relief from the discomfort. However, it is important to consult a qualified homeopathic practitioner for the correct dosage and duration of treatment. Homeo Care Clinic provides comprehensive care for various ailments and offers customized treatment plans based on individual requirements.
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