INTRODUCTION OF NON HOGKINS LYMPHOMA
Non-Hodgkin’s Lymphoma is a group of blood cancers that develop in the lymphatic system, which is a vital part of the body’s immune defense. It arises from abnormal, uncontrolled growth of lymphocytes. NHL can occur at any age but is common in adults. The disease involves lymph nodes, spleen, bone marrow, blood, or other organs outside the lymphatic system.
HOGKINS LYMPHOMA Vs NON HOGKINS LYMPHOMA
Hodgkin’s Lymphoma:
A cancer of the lymphatic system characterized by the presence of Reed–Sternberg cells. It’s common in young adults. It’s caused by Epstein-Barr virus infection, family history
and weakened immune system. This spreads in an orderly, predictable way from one lymph node group to the other. It starts in upper body lymph nodes.
Non-Hodgkin’s Lymphoma:
A diverse group of blood cancers that includes all lymphomas without Reed–Sternberg cells.
It’s more common in older adults.It’s caused by autoimmune diseases, Infections and immunosuppressive drugs. This spreads in a non-contiguous, unpredictable way, leads to extranodal sites.It occurs in lymph nodes of stomach, intestines, brain, or skin
CAUSES OF NON HOGKINS LYMPHOMA
A few factors increase the risk of developing the disease. These are:
-
Immune System Dysfunction
- Patients with weakened immune systems, due to conditions like HIV/AIDS.
- Patients on organ transplant and long-term immunosuppressive drugs
- Inherited immune disorders
-
Infections
- Chronic viral and bacterial infections, involved with NHL
- Epstein–Barr virus related to Burkitt’s lymphoma.
- Human T-cell leukemia or lymphotropic virus related to adult T-cell lymphoma.
- Helicobacter pylori infection related to gastric mucosa-associated lymphoid tissue lymphoma.
- Hepatitis C virus is related to B-cell lymphomas.
-
Genetic & Chromosomal Changes
- Mutations in lymphocyte DNA can lead to uncontrolled cell growth.
- The family history of lymphoma has a risk of the illness.
-
Environmental & Chemical Exposures:
- Pesticides
- Radiation exposure
-
Age & Gender
- In older adults, but can occur at any age.
- It’s more in men than women.
-
Autoimmune Disorders
The chronic immune stimulation leads to conditions like rheumatoid arthritis, celiac disease, Sjögren’s syndrome and lupus.
TYPES OF NON HOGKINS LYMPHOMA
Non-Hodgkin’s lymphoma is not a single disease but a group of related blood cancers. It’s classified as:
- The affected type of lymphocyte.
- The growth rate
- Based on Growth Rate
- Indolent NHL: This progresses slowly, with no symptoms for years and is not curable. But it’s managed for a long time such as follicular lymphoma, marginal zone lymphoma, small lymphocytic lymphoma.
- Aggressive NHL: This progresses quickly, needs immediate treatment, curable with timely therapy such as
- Diffuse large B-cell lymphoma
- Burkitt’s lymphoma
- Mantle cell lymphoma
- Peripheral T-cell lymphoma.
1. Based on Lymphocyte Origin
- B-cell Lymphomas:
- Diffuse large B-cell lymphoma: Most common aggressive type.
- Follicular lymphoma: Indolent form.
- Mantle cell lymphoma: Aggressive, with poor prognosis.
- Marginal zone lymphoma: MALT type related to infections.
- Burkitt’s lymphoma: highly aggressive, related to EBV.
- Small lymphocytic lymphoma: related to chronic lymphocytic leukemia.
2. T-cell and NK-cell Lymphomas
- Peripheral T-cell lymphoma: A group of aggressive T-cell lymphomas.
- Anaplastic large cell lymphoma: systemic or skin-limited.
- Angioimmunoblastic T-cell lymphoma.
- Adult T-cell leukemia/lymphoma: related to HTLV-1 infection.
- Extranodal NK/T-cell lymphoma, nasal type related to EBV.
SYMPTOMS OF NON HOGKINS LYMPHOMA AND ITS HOMOEOPATHIC APPROACH
Symptoms depend on the site of disease, growth rate and spread. In early indolent types, few remain symptom-free.
- General Symptoms:
These occur due to severity of disease such as
- unexplained fever
- Night sweats
- Unexplained weight loss
- Extreme fatigue.
1. Local Symptoms:
- Swollen Lymph Nodes: Painless swelling in the neck, armpits or groin.
2. Chest Symptoms:
- Persistent cough
- Shortness of breath
- Chest pain.
3. Abdominal Symptoms:
- Abdominal pain or swelling
- Loss of appetite, early fullness
- Nausea or vomiting.
4. Skin Symptoms:
- Itchy, red patches
- Nodules or plaques on the skin.
5. Symptoms of Bone Marrow Involvement:
- Repeated infections
- Shortness of breath
- Easy bruises and bleeding.
GENERAL APPROACH WITH SIDE EFFECTS OF NON HOGKINS LYMPHOMA:
- Diagnosis and Evaluation:
- History & Physical Exam – To check for swollen lymph nodes, organ enlargement, systemic symptoms.
- Blood Tests – CBC, LDH, liver & kidney function.
- Imaging – CT, PET-CT scans to detect spread.
- Lymph Node Biopsy – Gold standard, confirms NHL and subtype.
- Bone Marrow Biopsy – To check marrow involvement.
- Immunophenotyping & Genetic Tests – To classify NHL subtypes.
- Treatment Approach:
Choice depends on type, stage, patient’s age, overall health:
1.Watchful Waiting:
- For indolent or slow-growing NHL without symptoms.
- Regular monitoring, no immediate therapy.
2. Chemotherapy:
- Standard regimens like CHOP such as Cyclophosphamide, Doxorubicin, Vincristine, Prednisone.
- Other combined with targeted therapy.
- Immunotherapy / Targeted Therapy:
- Monoclonal antibodies (e.g., Rituximab – for B-cell lymphomas).
- CAR T-cell therapy in refractory cases.
3. Radiation Therapy:
- In localized disease or for controlling symptoms.
4. Stem Cell or Bone Marrow Transplant:
- In cases of relapsed or high-risk aggressive lymphomas.
5. Supportive Care:
- Growth factors, antibiotics, nutritional support, palliative care.
Side Effects of NHL Treatments
- Chemotherapy side Effects:
- Nausea, vomiting, diarrhea
- Hair loss
- Mouth sore
- Low blood counts
- Fatigue
- Immunotherapy side Effects:
- Fever, chills, allergic reactions
- Low blood pressure
- Risk of infections
- Targeted Therapy Side Effects:
- Infusion reactions
- Heart problems
- Cytokine release syndrome
- Radiation Therapy Side Effects
- Skin irritation at treatment site
- Fatigue
- Nausea
- Stem Cell Transplant Side Effects:
- Severe infections
- Graft-versus-host disease in allogeneic transplant
- Organ toxicity
DIET PLAN OF NON HOGKINS LYMPHOMA AND ITS SIDE EFFECTS
Diet Plan:
Early Morning: Warm water with lemon & honey or coconut water and a few almonds to be added.
Breakfast: Green tea, oats porridge with banana or Idli, dosa with chutney should be preferred.
Mid-morning: Papaya or pomegranate with green tea to be added.
Lunch: Salad, Brown rice or chapati with dal, green leafy veges and curd to be taken.
Evening snack: Vegetable soup with roasted chana or nuts to be taken.
Dinner: Quinoa or khichdi with paneer or grilled chicken or steamed vegetables can be taken.
Bedtime: Turmeric milk or chamomile tea should be preferred.
HOMOEOPATHIC APPROACH WITH FEW MEDICINES OF NON HOGKINS LYMPHOMA
Homoeopathy focuses on treatment on reducing lymph node swelling & tenderness, improving immune response and relieving fever, digestive issues supporting overall well-being.
Few Homeopathic Medicines in NHL:
- Conium maculatum: This medicine is indicated for hard, immovable lymph node swellings, in and around the neck , for patients with dizziness and glandular enlargement.
- Scrophularia nodosa: It is useful for glandular swellings and lymphatic tumors and heaviness in affected glands.
- Calcarea carbonica: It’s useful for chronic lymph node swellings, especially in overweight or easily fatigued patients, with sweating, night sweats, bone pains, and cold sensitivity.
- Phytolacca decandra: It’s useful for painful, tender cervical nodes, with burning or shooting pains and aching muscles.
- Arsenicum album: It’s useful for restlessness, anxiety, burning pains with fever, weight loss, and debility. It helps in palliative care.
FAQs OF NON HOGKINS LYMPHOMA:
- How is NHL diagnosed?
- Lymph node biopsy
- Blood tests
- Imaging
- Bone marrow biopsy
- Immunophenotyping/genetic tests to identify subtype.
- Is NHL curable?
- Indolent types: It’s not curable but is managed for years.
- Aggressive types: It’s curable with proper treatment.Prognosis depends on subtype, stage and overall health.
- What are the side effects of NHL treatment?
- Chemotherapy: Hair loss, nausea, infections, fatigue
- Immunotherapy: Fever, chills, allergic reactions
- Radiation: Skin irritation, fatigue
- Stem cell transplant: Severe infections, organ toxicity, GVHD.
- Can diet help in NHL management?
Yes. A well balanced, high-protein, antioxidant-rich diet supports immunity and recovery. Avoid raw, undercooked or contaminated food to prevent infection.
- Is there a role of homeopathy in the NHL?
Homeopathic approach improves general well-being, immunity, and reduces side effects, but it should not replace other treatments.
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